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AMD Instinct MI210 vs AMD Radeon RX 6400: Comparison
AMD Instinct MI210 and AMD Radeon RX 6400 separate most on tdp: AMD Instinct MI210 at 300 W, AMD Radeon RX 6400 at 53 W, 466% in favour of AMD Radeon RX 6400. Memory Bus Width splits them by another 98%, this time favouring AMD Instinct MI210.
Specs
| Specification | ![]() | ![]() |
|---|---|---|
| GPU Brand | AMD | AMD |
| Series | Instinct MI200 | Radeon RX 6000 |
| Board Partner | AMD Reference (PCIe dual-slot card, data center/OEM only) | Reference |
| VRAM | 64 GB | 4 GB-94% |
| Tier | Datacenter / AI Accelerator | Entry |
| Memory Type | HBM2E | GDDR6 |
| Boost Clock | 1700 MHz-27% | 2321 MHz |
| Ray Tracing Support | false | Yes |
| TDP | 300 W-466% | 53 W |
| Architecture | CDNA 2 (single Graphics Compute Die) | RDNA 2 |
| Slot Width | 2 (dual-slot, passive cooling for server airflow) | 1 |
| Memory Bus Width | 4096 bit | 64 bit-98% |
| Memory Bandwidth | 1600 GB/s | 128 GB/s-92% |
| Launch Date | 2022-03 | 2022-01-19 |
Verdict
AMD Instinct MI210
7.3 / 10 Expert Rating
A practical, PCIe-slot-friendly way to get CDNA 2 compute into a standard server, useful for smaller HPC and AI deployments, but clearly the entry point of its generation next to the dual-die MI250X and now well behind the MI300 series.
AMD Radeon RX 6400
5.5 / 10 Expert Rating
A solid entry-level pick if its price and 4GB VRAM allocation match your target resolution.




