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AMD Instinct MI210 vs AMD Radeon Pro WX 4100: Comparison
AMD Instinct MI210 and AMD Radeon Pro WX 4100 separate most on tdp: AMD Instinct MI210 at 300 W, AMD Radeon Pro WX 4100 at 50 W, 500% in favor of AMD Radeon Pro WX 4100. Memory Bus Width splits them by another 97%, this time favoring AMD Instinct MI210.
Pick the AMD Instinct MI210 if that matters to you: 16x the VRAM (64 GB vs 4 GB), which matters at 1440p and 4K with high texture settings. Pick the AMD Radeon Pro WX 4100 if that matters to you: 6x the TDP (50 W vs 300 W), so it needs a smaller power supply and runs cooler.
Which is better, AMD Instinct MI210 or AMD Radeon Pro WX 4100?
On paper, AMD Radeon Pro WX 4100 has the edge on tdp, at 50 W vs AMD Instinct MI210 at 300 W.
What is the main difference between AMD Instinct MI210 and AMD Radeon Pro WX 4100?
The AMD Instinct MI210 and AMD Radeon Pro WX 4100 are built for different jobs. The AMD Instinct MI210 has 16x the VRAM (64 GB vs 4 GB), which matters at 1440p and 4K with high texture settings. The AMD Radeon Pro WX 4100 has 6x the TDP (50 W vs 300 W), so it needs a smaller power supply and runs cooler.
Specs and benchmarks
GPU Brand
- AMD Instinct MI210
- AMD
- AMD Radeon Pro WX 4100
- AMD
Series
- AMD Instinct MI210
- Instinct MI200
- AMD Radeon Pro WX 4100
- Radeon PRO WX x100 Series
Board Partner
- AMD Instinct MI210
- AMD Reference (PCIe dual-slot card, data center/OEM only)
- AMD Radeon Pro WX 4100
- AMD (Reference)
VRAM
- AMD Instinct MI210
- 64 GBBest
- AMD Radeon Pro WX 4100
- 4 GB-94%
Memory Type
- AMD Instinct MI210
- HBM2E
- AMD Radeon Pro WX 4100
- GDDR5Best
TDP
- AMD Instinct MI210
- 300 W-500%
- AMD Radeon Pro WX 4100
- 50 WBest
Architecture
- AMD Instinct MI210
- CDNA 2 (single Graphics Compute Die)
- AMD Radeon Pro WX 4100
- Polaris
Card Length
- AMD Instinct MI210
- 267 mm-59%
- AMD Radeon Pro WX 4100
- 168 mmBest
Compute Blocks
- AMD Instinct MI210
- 104
- AMD Radeon Pro WX 4100
- 16
Memory Bus Width
- AMD Instinct MI210
- 4096 bitBest
- AMD Radeon Pro WX 4100
- 128 bit-97%
Memory Bandwidth
- AMD Instinct MI210
- 1600 GB/sBest
- AMD Radeon Pro WX 4100
- 96 GB/s-94%
PCIe Generation
- AMD Instinct MI210
- PCIe 4.0 x16
- AMD Radeon Pro WX 4100
- PCIe 3.0 x16 (x8 electrical)
Launch Date
- AMD Instinct MI210
- 2022-03
- AMD Radeon Pro WX 4100
- July 2016
Which one should you pick?
Choose AMD Instinct MI210 if you want the higher VRAM (64 GB vs 4 GB), the higher memory bus width (4096 bit vs 128 bit) and the higher memory bandwidth (1600 GB/s vs 96 GB/s).
Choose AMD Radeon Pro WX 4100 if you want the lower TDP (50 W vs 300 W) and the lower card length (168 mm vs 267 mm).
Verdict
AMD Instinct MI210
7.3 / 10 Expert Rating
A practical, PCIe-slot-friendly way to get CDNA 2 compute into a standard server, useful for smaller HPC and AI deployments, but clearly the entry point of its generation next to the dual-die MI250X and now well behind the MI300 series.




