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AMD Instinct MI210 vs AMD Radeon RX 590: Comparison
AMD Instinct MI210 and AMD Radeon RX 590 separate most on memory bus width: AMD Instinct MI210 at 4,096 bit, AMD Radeon RX 590 at 256 bit, 94% in favor of AMD Instinct MI210. VRAM splits them by another 88%, again favoring AMD Instinct MI210.
Pick the AMD Instinct MI210 if that matters to you: 8x the VRAM (64 GB vs 8 GB), which matters at 1440p and 4K with high texture settings. Pick the AMD Radeon RX 590 if that matters to you: 1.7x the TDP (175 W vs 300 W), so it needs a smaller power supply and runs cooler.
Which is better, AMD Instinct MI210 or AMD Radeon RX 590?
On paper, AMD Instinct MI210 has the edge on memory bus width, at 4,096 bit vs AMD Radeon RX 590 at 256 bit.
What is the main difference between AMD Instinct MI210 and AMD Radeon RX 590?
The AMD Instinct MI210 and AMD Radeon RX 590 are built for different jobs. The AMD Instinct MI210 has 8x the VRAM (64 GB vs 8 GB), which matters at 1440p and 4K with high texture settings. The AMD Radeon RX 590 has 1.7x the TDP (175 W vs 300 W), so it needs a smaller power supply and runs cooler.
Specs and benchmarks
GPU Brand
- AMD Instinct MI210
- AMD
- AMD Radeon RX 590
- AMD
Series
- AMD Instinct MI210
- Instinct MI200
- AMD Radeon RX 590
- Legacy
Board Partner
- AMD Instinct MI210
- AMD Reference (PCIe dual-slot card, data center/OEM only)
- AMD Radeon RX 590
- AMD (Reference)
VRAM
- AMD Instinct MI210
- 64 GBBest
- AMD Radeon RX 590
- 8 GB-87%
Memory Type
- AMD Instinct MI210
- HBM2E
- AMD Radeon RX 590
- GDDR5Best
Boost Clock
- AMD Instinct MI210
- 1700 MHzBest
- AMD Radeon RX 590
- 1545 MHz-9%
TDP
- AMD Instinct MI210
- 300 W-71%
- AMD Radeon RX 590
- 175 WBest
Architecture
- AMD Instinct MI210
- CDNA 2 (single Graphics Compute Die)
- AMD Radeon RX 590
- GCN
Process Node
- AMD Instinct MI210
- TSMC 6nm
- AMD Radeon RX 590
- Other
Compute Blocks
- AMD Instinct MI210
- 104
- AMD Radeon RX 590
- 36
Memory Bus Width
- AMD Instinct MI210
- 4096 bitBest
- AMD Radeon RX 590
- 256 bit-94%
Memory Bandwidth
- AMD Instinct MI210
- 1600 GB/sBest
- AMD Radeon RX 590
- 256 GB/s-84%
Launch Date
- AMD Instinct MI210
- 2022-03
- AMD Radeon RX 590
- 11/15/2018
Which one should you pick?
Choose AMD Instinct MI210 if you want the higher VRAM (64 GB vs 8 GB), the higher boost clock (1700 MHz vs 1545 MHz) and the higher memory bus width (4096 bit vs 256 bit).
Choose AMD Radeon RX 590 if you want the lower TDP (175 W vs 300 W).
Verdict
AMD Instinct MI210
7.3 / 10 Expert Rating
A practical, PCIe-slot-friendly way to get CDNA 2 compute into a standard server, useful for smaller HPC and AI deployments, but clearly the entry point of its generation next to the dual-die MI250X and now well behind the MI300 series.




