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AMD Instinct MI250 vs NVIDIA Quadro RTX 6000: Comparison
AMD Instinct MI250 and NVIDIA Quadro RTX 6000 differ on memory type: AMD Instinct MI250 at HBM2E, NVIDIA Quadro RTX 6000 at GDDR6, which puts NVIDIA Quadro RTX 6000 ahead on that measure.
Specs
| Specification | ![]() | ![]() |
|---|---|---|
| GPU Brand | AMD | NVIDIA |
| Series | Instinct MI200 Series | Quadro RTX |
| Board Partner | AMD (Reference) | PNY / NVIDIA Reference |
| Memory Type | HBM2E | GDDR6 |
| TDP | 500W | 560W Peak | 260 W |
| Architecture | CDNA2 | Turing |
| Memory ECC Support | Yes (Full-Chip) | Yes |
| PCIe Interface | PCIe 4.0 x16 | PCIe 3.0 x16 |
Verdict
NVIDIA Quadro RTX 6000
6.3 / 10 Expert Rating
The value half of NVIDIA's Turing workstation flagship pair; a solid used CAD/VFX card today, though NVIDIA's RTX PRO Ada and Blackwell cards outperform it significantly per watt.




