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AMD Instinct MI250 vs AMD Radeon RX 9050: Comparison
Instinct MI250 vs Radeon RX 9050: the tdp difference
The gap that matters here is tdp: Instinct MI250 500 W against Radeon RX 9050 92 W, which puts Radeon RX 9050 443% ahead. Add memory bandwidth to that, 3200 GB/s on the Instinct MI250 versus 144 GB/s on the Radeon RX 9050, and the pattern holds. Add memory bus width to that, 8192 bit on the Instinct MI250 versus 64 bit on the Radeon RX 9050, and the pattern holds. Boost clock runs the same way, 1700 MHz on the Instinct MI250 versus 2600 MHz on the Radeon RX 9050, another win for Radeon RX 9050. Board partner is not the same on both, Reference on the Instinct MI250 versus AMD on the Radeon RX 9050. They differ on tier too, Datacenter on the Instinct MI250 versus Entry on the Radeon RX 9050.
Who each one is for
The Instinct MI250 is the one to take for buyers comparing AMD's official reference specifications and researching a chip before choosing a board-partner card, though it is not built for overclocking-focused enthusiasts (reference clocks only). Avoid it for buyers wanting a specific retail card with cooler and warranty details. The Radeon RX 9050 suits buyers comparing AMD's official reference specifications and researching a chip before choosing a board-partner card, though it is not the pick for overclocking-focused enthusiasts (reference clocks only). It is not the one for buyers wanting a specific retail card with cooler and warranty details.
Frequently asked questions
Do the Instinct MI250 and Radeon RX 9050 differ on vram capacity?
Yes. VRAM Capacity reads 128 GB on the Instinct MI250 versus 4 GB on the Radeon RX 9050.
Is the GPU Brand the same on the Instinct MI250 and Radeon RX 9050?
It is. Both are listed at AMD, so it is not a reason to pick one over the other.
Specs and benchmarks
GPU Brand
- AMD Instinct MI250
- AMD
- AMD Radeon RX 9050
- AMD
Product Type
- AMD Instinct MI250
- Datacenter Accelerator
- AMD Radeon RX 9050
- Desktop Add-In Card
Series
- AMD Instinct MI250
- Instinct
- AMD Radeon RX 9050
- Radeon RX 9000 Series
Board Partner
- AMD Instinct MI250
- Reference
- AMD Radeon RX 9050
- AMD (Reference)
Tier
- AMD Instinct MI250
- Datacenter
- AMD Radeon RX 9050
- Entry
Memory Type
- AMD Instinct MI250
- HBM2E
- AMD Radeon RX 9050
- GDDR6Best
Boost Clock
- AMD Instinct MI250
- 1700 MHz-35%
- AMD Radeon RX 9050
- 2600 MHzBest
TDP
- AMD Instinct MI250
- 500 W-443%
- AMD Radeon RX 9050
- 92 WBest
Architecture
- AMD Instinct MI250
- CDNA2
- AMD Radeon RX 9050
- RDNA 4
Process Node
- AMD Instinct MI250
- TSMC 6nm FinFET
- AMD Radeon RX 9050
- TSMC N4P
Shader Units
- AMD Instinct MI250
- 13312
- AMD Radeon RX 9050
- 1024
Compute Blocks
- AMD Instinct MI250
- 208
- AMD Radeon RX 9050
- 16
VRAM Capacity
- AMD Instinct MI250
- 128 GBBest
- AMD Radeon RX 9050
- 4 GB
Memory Bus Width
- AMD Instinct MI250
- 8192 bitBest
- AMD Radeon RX 9050
- 64 bit-99%
Memory Bandwidth
- AMD Instinct MI250
- 3200 GB/sBest
- AMD Radeon RX 9050
- 144 GB/s-95%
PCIe Generation
- AMD Instinct MI250
- PCIe 4.0
- AMD Radeon RX 9050
- PCIe 5.0 x16
Form Factor
- AMD Instinct MI250
- OAM Module
- AMD Radeon RX 9050
- Desktop
Which one should you pick?
Choose AMD Instinct MI250 if you want the higher memory bus width (8192 bit vs 64 bit) and the higher memory bandwidth (3200 GB/s vs 144 GB/s).
Choose AMD Radeon RX 9050 if you want the higher boost clock (2600 MHz vs 1700 MHz) and the lower TDP (92 W vs 500 W).




