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AMD Instinct MI100 vs AMD FirePro S4000X: Comparison
Instinct MI100 vs FirePro S4000X: the tdp difference
Start with tdp, because it is the widest measured gap between them: Instinct MI100 300 W against FirePro S4000X 45 W, 567% in favour of FirePro S4000X. Instinct MI100 also leads on memory bandwidth, 1200 GB/s on the Instinct MI100 versus 72 GB/s on the FirePro S4000X. Vram capacity is closer, 32 GB on the Instinct MI100 versus 2 GB on the FirePro S4000X. They differ on tier too, Datacenter on the Instinct MI100 versus Workstation on the FirePro S4000X. On memory type there is little in it, HBM2 on the Instinct MI100 versus GDDR5 on the FirePro S4000X. They differ on architecture too, CDNA on the Instinct MI100 versus GCN on the FirePro S4000X. Shader units is not the same on both, 7680 on the Instinct MI100 versus 640 on the FirePro S4000X. There is a split on compute blocks as well, 120 on the Instinct MI100 versus 10 on the FirePro S4000X. Pcie generation is not the same on both, PCIe 4.0 on the Instinct MI100 versus PCIe 3.0 on the FirePro S4000X.
Which should you buy, Instinct MI100 or FirePro S4000X?
The Instinct MI100 is the one to take for buyers comparing AMD's official reference specifications and researching a chip before choosing a board-partner card, though it is not the pick for overclocking-focused enthusiasts (reference clocks only). It is the wrong buy for buyers wanting a specific retail card with cooler and warranty details. Buy the FirePro S4000X for buyers comparing AMD's official reference specifications and researching a chip before choosing a board-partner card, though it is not built for overclocking-focused enthusiasts (reference clocks only). It is not the one for buyers wanting a specific retail card with cooler and warranty details.
What Instinct MI100 and FirePro S4000X have in common
Everything else lines up. Gpu brand, board partner, pcie lanes and cooling type read the same on both, so those are not worth weighing.
Frequently asked questions
Do the Instinct MI100 and FirePro S4000X differ on ecc memory?
Yes. ECC Memory reads Yes on the Instinct MI100 versus No on the FirePro S4000X.
Specs and benchmarks
GPU Brand
- AMD Instinct MI100
- AMD
- AMD FirePro S4000X
- AMD
Series
- AMD Instinct MI100
- Instinct
- AMD FirePro S4000X
- Legacy
Board Partner
- AMD Instinct MI100
- Reference
- AMD FirePro S4000X
- Reference
Tier
- AMD Instinct MI100
- Datacenter
- AMD FirePro S4000X
- Workstation
Memory Type
- AMD Instinct MI100
- HBM2
- AMD FirePro S4000X
- GDDR5Best
TDP
- AMD Instinct MI100
- 300 W-567%
- AMD FirePro S4000X
- 45 WBest
Architecture
- AMD Instinct MI100
- CDNA
- AMD FirePro S4000X
- GCN
Process Node
- AMD Instinct MI100
- TSMC 7nm FinFET
- AMD FirePro S4000X
- Other
Shader Units
- AMD Instinct MI100
- 7680
- AMD FirePro S4000X
- 640
Compute Blocks
- AMD Instinct MI100
- 120
- AMD FirePro S4000X
- 10
VRAM Capacity
- AMD Instinct MI100
- 32 GBBest
- AMD FirePro S4000X
- 2 GB
Memory Bandwidth
- AMD Instinct MI100
- 1200 GB/sBest
- AMD FirePro S4000X
- 72 GB/s-94%
PCIe Generation
- AMD Instinct MI100
- PCIe 4.0
- AMD FirePro S4000X
- PCIe 3.0
PCIe Lanes
- AMD Instinct MI100
- 16
- AMD FirePro S4000X
- 16
Cooling Type
- AMD Instinct MI100
- Passive
- AMD FirePro S4000X
- Passive
Launch Date
- AMD Instinct MI100
- 11/16/2020
- AMD FirePro S4000X
- August 2014
ECC Memory
- AMD Instinct MI100
- Yes
- AMD FirePro S4000X
- No
Form Factor
- AMD Instinct MI100
- PCIe Add-in Card
- AMD FirePro S4000X
- Servers
Which one should you pick?
Choose AMD Instinct MI100 if you want the higher memory bandwidth (1200 GB/s vs 72 GB/s) and the higher PCIe lanes (16 vs 16).
Choose AMD FirePro S4000X if you want the lower TDP (45 W vs 300 W).




