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AMD Instinct MI210 vs AMD FirePro W4300: Comparison
What is the difference between Instinct MI210 and FirePro W4300?
On tdp the spread is 500%, Instinct MI210 300 W against FirePro W4300 50 W, so FirePro W4300 takes it. Vram runs the same way, 64 GB on the Instinct MI210 versus 4 GB on the FirePro W4300, another win for Instinct MI210. Instinct MI210 also leads on memory bandwidth, 1600 GB/s on the Instinct MI210 versus 96 GB/s on the FirePro W4300. Add boost clock to that, 1700 MHz on the Instinct MI210 versus 930 MHz on the FirePro W4300, and the pattern holds. Instinct MI210 also leads on memory bus width, 4096 bit on the Instinct MI210 versus 128 bit on the FirePro W4300. Add card length to that, 267 mm on the Instinct MI210 versus 168 mm on the FirePro W4300, and the pattern holds.
Which should you buy, Instinct MI210 or FirePro W4300?
The Instinct MI210 is the one to take for double-precision workloads that don't need MI250X-level throughput, though it is not the pick for any desktop or workstation build - compute-only, no display output and maximum-throughput HPC nodes (use MI250X instead). It is equally the pick for HPC and AI deployments in standard PCIe-slot servers without OAM sled support. The FirePro W4300 suits buyers comparing AMD's official reference specifications and researching a chip before choosing a board-partner card, though it is the wrong buy for overclocking-focused enthusiasts (reference clocks only). It is the wrong buy for buyers wanting a specific retail card with cooler and warranty details.
Frequently asked questions
Do the Instinct MI210 and FirePro W4300 differ on board partner?
Yes. Board Partner reads AMD Reference on the Instinct MI210 versus Reference on the FirePro W4300.
Is the GPU Brand the same on the Instinct MI210 and FirePro W4300?
It is. Both are listed at AMD, so it is not a reason to pick one over the other.
Specs and benchmarks
GPU Brand
- AMD Instinct MI210
- AMD
- AMD FirePro W4300
- AMD
Series
- AMD Instinct MI210
- Instinct MI200
- AMD FirePro W4300
- Legacy
Board Partner
- AMD Instinct MI210
- AMD Reference (PCIe dual-slot card, data center/OEM only)
- AMD FirePro W4300
- Reference
VRAM
- AMD Instinct MI210
- 64 GBBest
- AMD FirePro W4300
- 4 GB-94%
Tier
- AMD Instinct MI210
- Datacenter / AI Accelerator
- AMD FirePro W4300
- Workstation
Memory Type
- AMD Instinct MI210
- HBM2E
- AMD FirePro W4300
- GDDR5Best
Boost Clock
- AMD Instinct MI210
- 1700 MHzBest
- AMD FirePro W4300
- 930 MHz-45%
TDP
- AMD Instinct MI210
- 300 W-500%
- AMD FirePro W4300
- 50 WBest
Architecture
- AMD Instinct MI210
- CDNA 2 (single Graphics Compute Die)
- AMD FirePro W4300
- GCN
Card Length
- AMD Instinct MI210
- 267 mm-59%
- AMD FirePro W4300
- 168 mmBest
Memory Bus Width
- AMD Instinct MI210
- 4096 bitBest
- AMD FirePro W4300
- 128 bit-97%
Memory Bandwidth
- AMD Instinct MI210
- 1600 GB/sBest
- AMD FirePro W4300
- 96 GB/s-94%
PCIe Generation
- AMD Instinct MI210
- PCIe 4.0 x16
- AMD FirePro W4300
- PCIe 3.0
Launch Date
- AMD Instinct MI210
- 2022-03
- AMD FirePro W4300
- December 2015
Which one should you pick?
Choose AMD Instinct MI210 if you want the higher VRAM (64 GB vs 4 GB), the higher boost clock (1700 MHz vs 930 MHz) and the higher memory bus width (4096 bit vs 128 bit).
Choose AMD FirePro W4300 if you want the lower TDP (50 W vs 300 W) and the lower card length (168 mm vs 267 mm).
Verdict
AMD Instinct MI210
7.3 / 10 Expert Rating
A practical, PCIe-slot-friendly way to get CDNA 2 compute into a standard server, useful for smaller HPC and AI deployments, but clearly the entry point of its generation next to the dual-die MI250X and now well behind the MI300 series.




