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AMD Instinct MI250 vs NVIDIA CMP 50HX: Comparison
AMD Instinct MI250 vs NVIDIA CMP 50HX: the tdp difference
The gap that matters here is tdp: AMD Instinct MI250 500 W against NVIDIA CMP 50HX 225 W, which puts NVIDIA CMP 50HX 122% ahead. AMD Instinct MI250 also leads on memory bandwidth, 3200 GB/s on the AMD Instinct MI250 versus 448 GB/s on the NVIDIA CMP 50HX. AMD Instinct MI250 also leads on memory bus width, 8192 bit on the AMD Instinct MI250 versus 256 bit on the NVIDIA CMP 50HX. There is a split on tier as well, Datacenter on the AMD Instinct MI250 versus Mid-Level Mining on the NVIDIA CMP 50HX. They differ on architecture too, CDNA2 on the AMD Instinct MI250 versus Ampere , the first Ampere-based tier of the CMP... on the NVIDIA CMP 50HX.
AMD Instinct MI250 vs NVIDIA CMP 50HX: which one fits your build
The AMD Instinct MI250 is the one to take for buyers comparing AMD's official reference specifications and researching a chip before choosing a board-partner card, though it is the wrong buy for overclocking-focused enthusiasts (reference clocks only). Avoid it for buyers wanting a specific retail card with cooler and warranty details. The NVIDIA CMP 50HX suits secondary-market buyers mining non-Ethereum proof-of-work coins and repurposing as a cheap compute card for non-graphics CUDA workloads. It is not the one for gaming, no display output at all, cannot drive a monitor under any configuration. Our rating of the NVIDIA CMP 50HX (3.5/10): capable Ampere-generation mining silicon in its day, now a niche secondary-market product with no display output and diminished relevance after Ethereum's Merge.
Frequently asked questions
Do the AMD Instinct MI250 and NVIDIA CMP 50HX differ on boost clock?
Yes. Boost Clock reads 1700 MHz on the AMD Instinct MI250 versus 1665 MHz on the NVIDIA CMP 50HX.
Specs and benchmarks
GPU Brand
- AMD Instinct MI250
- AMD
- NVIDIA CMP 50HX
- NVIDIA
Series
- AMD Instinct MI250
- Instinct
- NVIDIA CMP 50HX
- CMP (Cryptocurrency Mining Processor)
Board Partner
- AMD Instinct MI250
- Reference
- NVIDIA CMP 50HX
- ASUS, Colorful, Gigabyte, Inno3D, MSI, Palit, Zotac (reference blower design)
Tier
- AMD Instinct MI250
- Datacenter
- NVIDIA CMP 50HX
- Mid-Level Mining (2021)
Memory Type
- AMD Instinct MI250
- HBM2E
- NVIDIA CMP 50HX
- GDDR6Best
Boost Clock
- AMD Instinct MI250
- 1700 MHzBest
- NVIDIA CMP 50HX
- 1665 MHz-2%
TDP
- AMD Instinct MI250
- 500 W-122%
- NVIDIA CMP 50HX
- 225 WBest
Architecture
- AMD Instinct MI250
- CDNA2
- NVIDIA CMP 50HX
- Ampere (GA104), the first Ampere-based tier of the CMP lineup
Process Node
- AMD Instinct MI250
- TSMC 6nm FinFET
- NVIDIA CMP 50HX
- Samsung 8nm (8N)
Slot Width
- AMD Instinct MI250
- Not Applicable
- NVIDIA CMP 50HX
- 2
Shader Units
- AMD Instinct MI250
- 13312
- NVIDIA CMP 50HX
- 3840
Memory Bus Width
- AMD Instinct MI250
- 8192 bitBest
- NVIDIA CMP 50HX
- 256 bit-97%
Memory Bandwidth
- AMD Instinct MI250
- 3200 GB/sBest
- NVIDIA CMP 50HX
- 448 GB/s-86%
PCIe Generation
- AMD Instinct MI250
- PCIe 4.0
- NVIDIA CMP 50HX
- PCIe 4.0 x4 (deliberately narrow lane count; mining needs almost no host bandwidth)
Launch Date
- AMD Instinct MI250
- 11/08/2021
- NVIDIA CMP 50HX
- 2021-03
Which one should you pick?
Choose AMD Instinct MI250 if you want the higher boost clock (1700 MHz vs 1665 MHz), the higher memory bus width (8192 bit vs 256 bit) and the higher memory bandwidth (3200 GB/s vs 448 GB/s).
Choose NVIDIA CMP 50HX if you want the lower TDP (225 W vs 500 W).
Verdict
NVIDIA CMP 50HX
3.5 / 10 Expert Rating
Capable Ampere-generation mining silicon in its day, now a niche secondary-market product with no display output and diminished relevance after Ethereum's Merge.




